RESEARCH PAPER
THE INFLUENCE OF HELICOBACTER PYLORI INFECTION ON VITAMIN
B12 ABSORPTION FROM THE GASTROINTESTINAL TRACT
1
z Katedry i Kliniki Chorób Wewnętrznych Uniwersytetu Medycznego w Lublinie
Med Og. 2009;15(2):268-275
KEYWORDS
ABSTRACT
Helicobacter pylori (HP) infection is considered the main cause of chronic active gastritis. Long-lasting infection may lead to atrophic gastritis, which may in turn impair vitamin B12 absorption caused by diminished secretions of hydrochloric acid and intrinsic factor (IF). The aim of the present study was to investigate the influence of HP infection on absorption of vitamin B12 and secretion of internal factor (IF). The IF secretion was evaluated indirectly by measuring of the area under the curve (AUC) for vitamin B12 absorption. Five blood plasma samples were harvested to measure plasma concentration of vitamin B12. This procedure was performed before and 3 weeks after HP
eradication. HP infection was confirmed by urease test in endoscopy samples. A total of 30 patients were included to the study. The average concentration of vitamin B12 increased from 326 to 412 pg/ml after HP eradication, and the AUC increased from 4643 to 5023 units (p=0.04).
In conclusion, it was confirmed that HP infection diminishes vitamin B12 absorption and IF secretion
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| eISSN: | 2084-4905 |
| ISSN: | 2083-4543 |
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