RESEARCH PAPER
Socio-demographic situation and environmental factors in childhood nephrotic syndrome
1
Oddział Pediatrii i Nefrologii ze Stacją Dializ, Dziecięcy Szpital Kliniczny w Lublinie
2
Klinika Nefrologii Dziecięcej, Uniwersytet Medyczny w Lublinie
3
Instytut Transportu, Silników Spalinowych i Ekologii, Wydział Mechaniczny, Politechnika Lubelska
Corresponding author
Aleksandra Sobieszczańska-Droździel
Oddział Pediatrii i Nefrologii ze Stacją Dializ, Dziecięcy Szpital Kliniczny w Lublinie, ul. Chodźki 2, 20-093 Lublin.
Oddział Pediatrii i Nefrologii ze Stacją Dializ, Dziecięcy Szpital Kliniczny w Lublinie, ul. Chodźki 2, 20-093 Lublin.
Med Og Nauk Zdr. 2013;19(1):13-20
KEYWORDS
ABSTRACT
Introduction:
At present, increasingly more attention is paid to the environmental determinants of health and disease. Broadly defined, environmental factors can cause not only the disease, but also can modify its course or prevent it.
Objective:
A retrospective evaluation of socio-demographic situation of patients with nephrotic syndrome (NS) and the influence of the selected environmental factors on its occurrence and course.
Material and Methods:
The study covered 123 children with NS hospitalized in the Department of Paediatric Nephrology in Lublin in 2008 – 2012. A questionnaire designed by the author was used, and the available medical documentation analyzed.
Results:
The age at onset was between 2 – 4 years in the majority of children. Most of the patients were steroid responsive. The resistance to glucocorticoid therapy and steroid dependency were more common in girls than in boys. There was a statistically significant relationship between age at onset and the sensitivity to glucocorticoid therapy. No significant relationship was observed between the place of residence, housing conditions, exposure to vehicle fumes or tobacco smoke, history of allergic diseases, birth weight, intrauterine growth retardation, smoking by the mother during pregnancy, and age at onset and evaluated parameters of the course of NS. The children with steroid resistant NS were breast-fed for the shortest time, but this was statistically insignificant.
Conclusions:
The study confirmed the association between the age at onset of NS and response to glucocorticoid therapy. No statistically significant relationship was found between the course of NS and selected socio-demographic and environmental factors.
At present, increasingly more attention is paid to the environmental determinants of health and disease. Broadly defined, environmental factors can cause not only the disease, but also can modify its course or prevent it.
Objective:
A retrospective evaluation of socio-demographic situation of patients with nephrotic syndrome (NS) and the influence of the selected environmental factors on its occurrence and course.
Material and Methods:
The study covered 123 children with NS hospitalized in the Department of Paediatric Nephrology in Lublin in 2008 – 2012. A questionnaire designed by the author was used, and the available medical documentation analyzed.
Results:
The age at onset was between 2 – 4 years in the majority of children. Most of the patients were steroid responsive. The resistance to glucocorticoid therapy and steroid dependency were more common in girls than in boys. There was a statistically significant relationship between age at onset and the sensitivity to glucocorticoid therapy. No significant relationship was observed between the place of residence, housing conditions, exposure to vehicle fumes or tobacco smoke, history of allergic diseases, birth weight, intrauterine growth retardation, smoking by the mother during pregnancy, and age at onset and evaluated parameters of the course of NS. The children with steroid resistant NS were breast-fed for the shortest time, but this was statistically insignificant.
Conclusions:
The study confirmed the association between the age at onset of NS and response to glucocorticoid therapy. No statistically significant relationship was found between the course of NS and selected socio-demographic and environmental factors.
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