Introduction:
Urolithiasis affects the young working population and due to frequent recurrences, accompanied by severe pain syndrome, leads to a feeling of discomfort, and reduces the quality of life of patients and their biological and social adaptive possibilities.

Objective:
To study the peculiarities of social, psychological and physiological adaptation of patients with urolithiasis in order to propose preventive measures.

Material and Methods:
A retrospective epidemiological study was conducted of a representative sample of 443 patients with urolithiasis: a study group – 403 patients without recurrences and 40 with recurrences, and a control group – 203 patients without urolithiasis, at their discharge from the urologic in-patient departments of health care facilities of Ivano-Frankivsk region, Ukraine.

Results:
It was established that urolithiasis is accompanied by psychological isolation of patients, manifested in the feeling of loneliness (OR = 1.44; 95% CI = 1.03–2.02). The social and psychological patient’ adaptation decreases with the recurrence of urolithiasis, as evidenced by the growth of odds of disability due to disease (4.39; 2.23–8.65), sleep disorders (3.91; 1.62–9.40), dependence of medicines (2.97; 1.49–5.93), dissatisfaction with life (2.67; 1.20–5.94) and health (2.45; 1.27–4.76), reduction in social contacts (2.24; 1.09–4.57), and pain (2.09; 1.24–3.51). Тhe occurrence of urolithiasis leads to tension, unsatisfactory status and breakdown of physiological adaptation mechanisms (1.64; 1.01–2.68), significantly enhanced with progression of disease (2.39; 1.03–5.57).

Conclusions:
The occurrence, and especially recurrence, of urolithiasis is accompanied by progression of social and psychological as well as physiological disadaptation. This should be considered in developing individual rehabilitation programmes