REVIEW PAPER
New antibiotics in clinical trials – prospects for antibacterial treatment development
1
Warszawski Uniwersytet Medyczny, Polska
2
Katedra i Zakład Farmakologii Doświadczalnej i Klinicznej, Warszawski Uniwersytet Medyczny, Polska
Corresponding author
Adriana Wawer
Katedra i Zakład Farmakologii Doświadczalnej i Klinicznej, Warszawski Uniwersytet Medyczny, Polska
Katedra i Zakład Farmakologii Doświadczalnej i Klinicznej, Warszawski Uniwersytet Medyczny, Polska
Med Og Nauk Zdr. 2023;29(2):73-78
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
The discovery of new compounds with antibacterial properties is one of the most important achievements of modern medicine. Unfortunately, the development of new resistance mechanisms and the relatively easy transfer of resistance genes between bacterial cells is now a huge threat and makes many antibiotics ineffective. There is a need to search for new chemical compounds with antibacterial activity, especially against pathogens with critical priority (multidrug-resistant bacteria – Acinetobacter baumanii and Pseudomonas aeruginosa resistant to carbapenems and Enterobacteriaceae producing β-lactamases and resistant to carbapenems and third generation cephalosporins). The aim of this article is to review current clinical trials on new antibacterial compounds.
Review methods:
A literature review was conducted using the PubMed, Google Scholar, Medline databases and the clinicaltrials.gov database, which collects data on clinical trials.
Abbreviated description of the state of knowledge:
According to a report published by the World Health Organization (WHO), 46 antibiotics are in various stages of clinical trials, of which 28 are potentially active against pathogens on the priority list. However, only 17 of these antibiotics fulfil at least one innovation criteria.
Summary:
The growing prevalence of multidrug-resistant bacteria is now an urgent public health issue. Antibiotic resistance of bacteria is a challenge that modern medicine has to face, it is increasingly said that we are approaching the beginning of the post-antibiotic era. According to the World Health Organization, recently approved antibiotics and those currently in clinical trials are not sufficient to spread drug resistance.
The discovery of new compounds with antibacterial properties is one of the most important achievements of modern medicine. Unfortunately, the development of new resistance mechanisms and the relatively easy transfer of resistance genes between bacterial cells is now a huge threat and makes many antibiotics ineffective. There is a need to search for new chemical compounds with antibacterial activity, especially against pathogens with critical priority (multidrug-resistant bacteria – Acinetobacter baumanii and Pseudomonas aeruginosa resistant to carbapenems and Enterobacteriaceae producing β-lactamases and resistant to carbapenems and third generation cephalosporins). The aim of this article is to review current clinical trials on new antibacterial compounds.
Review methods:
A literature review was conducted using the PubMed, Google Scholar, Medline databases and the clinicaltrials.gov database, which collects data on clinical trials.
Abbreviated description of the state of knowledge:
According to a report published by the World Health Organization (WHO), 46 antibiotics are in various stages of clinical trials, of which 28 are potentially active against pathogens on the priority list. However, only 17 of these antibiotics fulfil at least one innovation criteria.
Summary:
The growing prevalence of multidrug-resistant bacteria is now an urgent public health issue. Antibiotic resistance of bacteria is a challenge that modern medicine has to face, it is increasingly said that we are approaching the beginning of the post-antibiotic era. According to the World Health Organization, recently approved antibiotics and those currently in clinical trials are not sufficient to spread drug resistance.
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