REVIEW PAPER
Potential possibilities of using selected biologically-active substances in supporting pharmacological treatment of Crohn’s Disease – Review of trial results
1
Studenckie Koło Naukowe przy Zakładzie Dietetyki, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny, Wrocław
2
Zakład Dietetyki, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny, Wrocław
Corresponding author
Dorota Różańska
Zakład Dietetyki, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny we Wrocławiu, ul. Parkowa 34, 51-616 Wrocław
Zakład Dietetyki, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny we Wrocławiu, ul. Parkowa 34, 51-616 Wrocław
Med Og Nauk Zdr. 2015;21(4):346-351
KEYWORDS
ABSTRACT
Introduction:
Crohn’s Disease (CD) is a chronic and incurable, inflammatory bowel disease, that is characterized by periods of remissions and relapses. An improper diet may impair nutritional status, exacerbate the symptoms and shorten the duration of remission. The to-date dietary recommendations for the patients concern mainly the reduction of intake of the products that exacerbate the symptoms, as well as combating malnutrition.
Objective:
Review of the literature concerning the possibility of using certain biologically- active substances in supporting pharmacological treatment of Crohn’s Disease.
Scientific knowledge:
Certain substances, such as polyunsaturated fatty acids n-3, glutamine, probiotics, prebiotics and short-chain fatty acids may exhibit anti-inflammatory properties, primarily by regulating the number and composition of physiological gut microflora and inhibiting the expression of proinflammatory cytokines. Although the beneficial effects of using biologically-active substances have been confirmed in many in vitro and in vivo animal studies, the results of studies in humans are unclear. However, in most studies it has been revealed that those substances, despite their ineffectiveness, are probably safe and their use is not associated with an increased risk of side effects or exacerbation of patient›s condition.
Conclusion:
Therapy with the above-mentioned substances is not used for treatment Crohn’s Disease and the results of studies are inconclusive. Therefore, other studies with polyunsaturated fatty acids n-3, glutamine, probiotics, prebiotics and short-chain fatty acids are needed in order to determine their effectiveness on the treatment of Crohn’s Disease.
Crohn’s Disease (CD) is a chronic and incurable, inflammatory bowel disease, that is characterized by periods of remissions and relapses. An improper diet may impair nutritional status, exacerbate the symptoms and shorten the duration of remission. The to-date dietary recommendations for the patients concern mainly the reduction of intake of the products that exacerbate the symptoms, as well as combating malnutrition.
Objective:
Review of the literature concerning the possibility of using certain biologically- active substances in supporting pharmacological treatment of Crohn’s Disease.
Scientific knowledge:
Certain substances, such as polyunsaturated fatty acids n-3, glutamine, probiotics, prebiotics and short-chain fatty acids may exhibit anti-inflammatory properties, primarily by regulating the number and composition of physiological gut microflora and inhibiting the expression of proinflammatory cytokines. Although the beneficial effects of using biologically-active substances have been confirmed in many in vitro and in vivo animal studies, the results of studies in humans are unclear. However, in most studies it has been revealed that those substances, despite their ineffectiveness, are probably safe and their use is not associated with an increased risk of side effects or exacerbation of patient›s condition.
Conclusion:
Therapy with the above-mentioned substances is not used for treatment Crohn’s Disease and the results of studies are inconclusive. Therefore, other studies with polyunsaturated fatty acids n-3, glutamine, probiotics, prebiotics and short-chain fatty acids are needed in order to determine their effectiveness on the treatment of Crohn’s Disease.
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