Poisonings with pharmaceuticals, especially suicidal, are a serious toxicological problem. Sleep-inducing and psychotropic drugs are dominant. Amitryptyline, which is a psychotropic drug of the tricyclic antidepressants group, is applied in the treatment of depressions and post-traumatic neuroses. In curative doses, in patients with no contraindications, this is a safe medication, although all pharma-ceuticals of this group have a relatively narrow therapeutic scope, and the toxic dose is close to the curative dose. The authors describe the case of a 35-year-old male, who had been treated for many years due to anxiety and depression, who made a suicidal attempt by consuming 18 tablets of Amitryptyline 25 mg. He was admitted to the Toxicology Ward at the Institute of Agricultural Medicine in the state of a toxic coma, from which he awakened on the second day of treatment. During the clinical observa-tion, dysfunction of the femoral nerve was observed, which regressed, however incompletely, after application of treatment and decreasing of the level of Amitryptyline in patient’s blood