REVIEW PAPER
Glucocorticoids and the reproductive system
1
Katedra i Zakład Fizjologii, Uniwersytet Medyczny we Wrocławiu
2
Klinika Urologii i Onkologii Urologicznej, Uniwersytecki Szpital Kliniczny we Wrocławiu
3
Zakład Anatomii Prawidłowej, Uniwersytet Medyczny we Wrocławiu
Corresponding author
Anna Otlewska
Katedra i Zakład Fizjologii, Uniwersytet Medyczny we Wrocławiu, al. Wiązowa 7/1, 53-127 Wrocław, Polska
Katedra i Zakład Fizjologii, Uniwersytet Medyczny we Wrocławiu, al. Wiązowa 7/1, 53-127 Wrocław, Polska
Med Og Nauk Zdr. 2018;24(2):92-95
KEYWORDS
TOPICS
ABSTRACT
Glucocorticoids (GKS) are widely used in the treatment of various diseases due to their immunosuppressive and anti-inflammatory effects. Their influence on the occurrence of metabolic complications, the increase of cardiovascular risk or changes in external appearance, is well-known. However, glucocorticosteroids may also lead to various complications in the functioning of the reproductive system and may interfere with the normal course of pregnancy. On the other hand, it should also be remembered that GKS are used in the prevention of some obstetric complications. Most of the complications of steroid therapy result from the effect of glucocorticoids on the functioning of the hypothalamic-pituitary-gonads axis. Adverse effects on the part of the genital system associated with the reception of steroids include: menstrual disorders, impaired fertility, lower libido, development of hirustism and pregnancy-related complications, such as: foetal growth suppression, secondary foetal adrenal insufficiency or pre-eclampsia development in a pregnant woman. At the same time, GKS are used to stimulate foetal lung maturation when there is a threat of preterm delivery and in preventing the masculinization of the external genital organs and the risk of congenital adrenal hyperplasia. When choosing a therapy, it should be remembered that the individual glucocorticosteroids used in the therapy differ in their profile of action, including the degree of passage through the placenta, which has significant clinical consequences.
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