RESEARCH PAPER
Association between baseline characteristics and clinical outcomes among the elderly undergoing PCI –
retrospective cohort study
More details
Hide details
1
1st Department and Clinic of Cardiology, Medical University, Warsaw, Poland
Corresponding author
Mateusz Wawrzeńczyk
I Katedra i Klinika Kardiologii, Warszawski Uniwersytet Medyczny, Banacha 1a, 02-097, Warsaw, Polska
Med Og Nauk Zdr. 2023;29(3):187-195
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Percutaneous coronary intervention (PCI) is the method of choice for the treatment of coronary artery disease or acute coronary syndromes, but clinicians often refrain from performing it on elderly and/or frail patients. The aimed of the study was to determine the feasibility of PCI in the elderly, and define characteristics of significant stenoses and clinical outcomes of those procedures.
Material and methods:
A retrospective analysis was conducted on a total of 150 patients aged ≥70 years, who were admitted and underwent PCI between November 2020 – December.2021. Also investgated was the impact of patients’ baseline characteristics, such as: gender, body mass index (BMI) or comorbidities: hyperlipidaemia, hypertension, diabetes, etc. on clinical outcomes of PCI performed in the elderly.
Results:
The mean age was 77.5 ± 7.1 years, 65.33% were male. The average BMI was 27.5 ± 4.3, 92.00% had a history of HT. The majority of patients (n=84) were treated for acute coronary syndromes (ACS). The mean length of stents implanted in one procedure was 31mm. The TIMI 3 flow was achieved in 94.67% of cases. Combined intra-procedural and in-hospital mortality was 2.67%.
Conclusions:
Complex PCI may be successfully and safely performed among elderly patients who frequently suffer from severe myocardial ischemia and carry a substantial comorbidity burden. Age itself cannot warrant disqualification from interventional management of coronary artery disease. Gender and BMI are potential factors that influence clinical outcomes.
REFERENCES (45)
1.
Virani SS, Alonso A, Aparicio HJ, et al. Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. Circulation. 2021;143(8):e254-e743.
https://dx.doi.org/10.1161/CIR....
2.
Gu D, Qu J, Zhang H, et al. Revascularization for Coronary Artery Disease: Principle and Challenges. Adv Exp Med Biol. 2020;1177:75–100.
https://dx.doi.org/10.1007/978....
3.
Brenes-Salazar JA, Forman DE Advances in percutaneous coronary interventions for elderly patients. Prog Cardiovasc Dis. 2014;57(2):176–186.
https://dx.doi.org/10.1016/j.p....
5.
Guo L, Lv HC, Huang RC Percutaneous Coronary Intervention in Elderly Patients with Coronary Chronic Total Occlusions: Current Evidence and Future Perspectives. Clin Interv Aging. 2020;15:771–781.
https://dx.doi.org/10.2147/CIA....
6.
Hannan EL, Racz M, Holmes DR, et al. Impact of completeness of percutaneous coronary intervention revascularization on long-term outcomes in the stent era. Circulation. 2006;113(20):2406–2412.
https://dx.doi.org/10.1161/CIR....
7.
Uchmanowicz I, Mlynarska A, Lisiak M, et al. Heart Failure and Problems with Frailty Syndrome: Why it is Time to Care About Frailty Syndrome in Heart Failure. Card Fail Rev. 2019;5(1):37–43.
https://dx.doi.org/10.15420/cf....
8.
Sanchez E, Vidan MT, Serra JA, et al. Prevalence of geriatric syndromes and impact on clinical and functional outcomes in older patients with acute cardiac diseases. Heart. 2011;97(19):1602–1606.
https://dx.doi.org/10.1136/hrt....
9.
Neumann FJ, Sousa-Uva M, Ahlsson A, et al. [2018 ESC/EACTS Guidelines on myocardial revascularization. The Task Force on myocardial revascularization of the European Society of Cardiology (ESC) and European Association for Cardio-Thoracic Surgery (EACTS)]. G Ital Cardiol (Rome). 2019;20(7–8 Suppl 1):1S–61S.
https://dx.doi.org/10.1714/320....
10.
Yuan L, Chang M, Wang J Abdominal obesity, body mass index and the risk of frailty in community-dwelling older adults: a systematic review and meta-analysis. Age Ageing. 2021;50(4):1118–1128.
https://dx.doi.org/10.1093/age....
12.
Wang JL, Guo CY, Chen H, et al. Improvement of long-term clinical outcomes by successful PCI in the very elderly women with ACS. BMC Cardiovasc Disord. 2021;21(1):122.
https://dx.doi.org/10.1186/s12....
13.
Kim JH, Choi W, Kim KC, et al. The Current Status of Intervention for Intermediate Coronary Stenosis in the Korean Percutaneous Coronary Intervention (K-PCI) Registry. Korean Circ J. 2019;49(11):1022–1032.
https://dx.doi.org/10.4070/kcj....
14.
Antoni ML, Yiu KH, Atary JZ, et al. Distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention. Coron Artery Dis. 2011;22(8):533–536.
https://dx.doi.org/10.1097/MCA....
15.
Wasilewski J, Roleder M, Niedziela J, et al. The role of septal perforators and „myocardial bridging effect” in atherosclerotic plaque distribution in the coronary artery disease. Pol J Radiol. 2015;80:195–201.
https://dx.doi.org/10.12659/PJ....
16.
Kim MC, Ahn Y, Sun Sim D, et al. Comparison of the planned one- and elective two-stent techniques in patients with coronary bifurcation lesions with or without acute coronary syndrome from the COBIS II Registry. Catheter Cardiovasc Interv. 2018;92(6):1050–1060.
https://dx.doi.org/10.1002/ccd....
17.
Nasir M, Shafique HM, Hussain S, et al. Percutaneous Coronary Intervention for Left Main Coronary Artery Bifurcation Lesions: Two-stent versus one-stent Strategy for Comparison of 6-month MACE. J Coll Physicians Surg Pak. 2020;30(9):894–899.
https://dx.doi.org/10.29271/jc....
18.
Arif S, Bartus S, Rakowski T, et al. Comparison of radiation dose exposure in patients undergoing percutaneous coronary intervention vs. peripheral intervention. Postepy Kardiol Interwencyjnej. 2014;10(4):308–313.
https://dx.doi.org/10.5114/pwk....
19.
Ekenback C, Jokhaji F, Ostlund-Papadogeorgos N, et al. Changes in Index of Microcirculatory Resistance during PCI in the Left Anterior Descending Coronary Artery in Relation to Total Length of Implanted Stents. J Interv Cardiol. 2019;2019:1397895.
https://dx.doi.org/10.1155/201....
20.
Januszek RA, Bryniarski L, Siudak Z, et al. Predictors and trends of contrast use and radiation exposure in a large cohort of patients treated with percutaneous coronary interventions: Chronic total occlusion analysis based on a national registry. Cardiol J. 2021.
https://dx.doi.org/10.5603/CJ.....
21.
World Health O: WHO clinical consortium on healthy ageing: topic focus: frailty and intrinsic capacity: report of consortium meeting,1–2 December 2016 in Geneva, Switzerland. In. Geneva: World Health Organization; 2017.
22.
Salaffi F, Farah S, Di Carlo M. Frailty syndrome in rheumatoid arthritis and symptomatic osteoarthritis: an emerging concept in rheumatology. Acta Biomed. 2020;91(2):274–296.
https://dx.doi.org/10.23750/ab....
23.
Kane AE, Howlett SE Sex differences in frailty: Comparisons between humans and preclinical models. Mech Ageing Dev. 2021;198:111546.
https://dx.doi.org/10.1016/j.m....
24.
Kosmidou I, Leon MB, Zhang Y, et al. Long-Term Outcomes in Women and Men Following Percutaneous Coronary Intervention. J Am Coll Cardiol. 2020;75(14):1631–1640.
https://dx.doi.org/10.1016/j.j....
25.
Lee CY, Liu KT, Lu HT, et al. Sex and gender differences in presentation, treatment and outcomes in acute coronary syndrome, a 10 year study from a multi-ethnic Asian population: The Malaysian National Cardiovascular Disease Database-Acute Coronary Syndrome (NCVD-ACS) registry. PLoS One. 2021;16(2):e0246474.
https://dx.doi.org/10.1371/jou....
26.
Birkemeyer R, Schneider H, Rillig A, et al. Do gender differences in primary PCI mortality represent a different adherence to guideline recommended therapy? a multicenter observation. BMC Cardiovasc Disord. 2014;14:71.
https://dx.doi.org/10.1186/147....
27.
Guelker JE, Bansemir L, Ott R, et al. Gender-based acute outcome in percutaneous coronary intervention of chronic total coronary occlusion. Neth Heart J. 2017;25(5):304–311.
https://dx.doi.org/10.1007/s12....
28.
Tang L, Cui QW, Liu DP, et al. The number of stents was an independent risk of stent restenosis in patients undergoing percutaneous coronary intervention. Medicine (Baltimore). 2019;98(50):e18312.
https://dx.doi.org/10.1097/md.....
29.
Li Q, Liu S, Myers KJ, et al. Impact of Reconstruction Algorithms and Gender-Associated Anatomy on Coronary Calcium Scoring with CT: An Anthropomorphic Phantom Study. Acad Radiol. 2016;23(12):1470–1479.
https://dx.doi.org/10.1016/j.a....
30.
Siudak Z, Bryniarski L, Malinowski KP, et al. Procedural Outcomes in Patients Treated with Percutaneous Coronary Interventions within Chronic Total Occlusions Stratified by Gender. J Clin Med. 2022;11(5).
https://dx.doi.org/10.3390/jcm....
31.
Watanabe D, Yoshida T, Watanabe Y, et al. A U-Shaped Relationship Between the Prevalence of Frailty and Body Mass Index in Community-Dwelling Japanese Older Adults: The Kyoto-Kameoka Study. J Clin Med. 2020;9(5).
https://dx.doi.org/10.3390/jcm....
32.
Khan SS, Ning H, Wilkins JT, et al. Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity. JAMA Cardiol. 2018;3(4):280–287.
https://dx.doi.org/10.1001/jam....
33.
Crowhurst J, Savage M, Hay K, et al. Impact of Patient BMI on Patient and Operator Radiation Dose During Percutaneous Coronary Intervention. Heart Lung Circ. 2022;31(3):372–382.
https://dx.doi.org/10.1016/j.h....
34.
Jankowska-Polańska B, Zamęta K, Uchmanowicz I, et al. Adherence to pharmacological and non-pharmacological treatment of frail hypertensive patients. J Geriatr Cardiol. 2018;15(2):153–161.
https://dx.doi.org/10.11909/j.....
35.
Kala P, Kanovsky J, Rokyta R, et al. Age-related treatment strategy and long-term outcome in acute myocardial infarction patients in the PCI era. BMC Cardiovasc Disord. 2012;12:31.
https://dx.doi.org/10.1186/147....
36.
Vetrano DL, Palmer KM, Galluzzo L, et al. Hypertension and frailty: a systematic review and meta-analysis. BMJ Open. 2018;8(12):e024406.
https://dx.doi.org/10.1136/bmj....
37.
Mouton AJ, Li X, Hall ME, et al. Obesity, Hypertension, and Cardiac Dysfunction: Novel Roles of Immunometabolism in Macrophage Activation and Inflammation. Circ Res. 2020;126(6):789–806.
https://dx.doi.org/10.1161/cir....
39.
Boden WE, O'Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356(15):1503–1516.
https://dx.doi.org/10.1056/NEJ....
40.
Iannaccone M, D'Ascenzo F, Piazza F, et al. Optimal medical therapy vs. coronary revascularization for patients presenting with chronic total occlusion: A meta-analysis of randomized controlled trials and propensity score adjusted studies. Catheter Cardiovasc Interv. 2019;93(6):E320–E325.
https://dx.doi.org/10.1002/ccd....
41.
Shaw LJ, Berman DS, Maron DJ, et al. Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy. Circulation. 2008;117(10):1283–1291.
https://dx.doi.org/10.1161/CIR....
42.
Werner GS, Martin-Yuste V, Hildick-Smith D, et al. A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions. Eur Heart J. 2018;39(26):2484–2493.
https://dx.doi.org/10.1093/eur....
43.
Eisenberg MJ, Afilalo J, Lawler PR, et al. Cancer risk related to low -dose ionizing radiation from cardiac imaging in patients after acute myocardial infarction. CMAJ. 2011;183(4):430–436.
https://dx.doi.org/10.1503/cma....
44.
Kim DW, Her SH, Park MW, et al. Impact of Postprocedural TIMI Flow on Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction. Int Heart J. 2017;58(5):674–685.
https://dx.doi.org/10.1536/ihj....
45.
Chiarito M, Cao D, Nicolas J, et al. Radial versus femoral access for coronary interventions: An updated systematic review and meta-analysis of randomized trials. Catheter Cardiovasc Interv. 2021;97(7):1387–1396.
https://dx.doi.org/10.1002/ccd....