REVIEW PAPER
Pharmacological activity of essential oils and their components in the treatment of gastrointestinal diseases
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1
Samodzielna Pracownia Biologii Molekularnej, Instytut Medycyny Wsi w Lublinie
2
Katedra i Zakład Biochemii i Biologii Molekularnej, Uniwersytet Medyczny w Lublinie
3
Katedra Zdrowia Publicznego, Wyższa Szkoła Informatyki i Zarządzania w Rzeszowie
Med Og Nauk Zdr. 2011;17(4):202-205
KEYWORDS
ABSTRACT
Introduction:
Essential oils are natural, multi-component mixtures, commonly found in the world of plants. The use of raw plant materials,
rich in essential oils for culinary and therapeutic purposes, is almost as old as humanity. It is also well-known that the use
of herbs and the aromatic parts of plants improves the fl avor and fragrance of many dishes, and simultaneously exerts an
extremely benefi cial eff ect on the gastrointestinal system. The objective of the presented study was the presentation of
the current state of knowledge concerning the pharmacological properties of essential oils and their selected components
on the gastrointestinal system. The article reviews the in vitro and in vivo studies confi rming that selected essential oils
and some of their components show a wide range of activities. Furthermore, the article also shows the potential mechanisms
of action of selected essential oils and their individual compounds (terpenes). Some reports from literature indicate
a spasmolytic and antidiarrheal activity of essential oils commonly occurring in many plant raw materials. The essential
oils of well-known, domestic, and some exotic plants have been reported to show hepatoprotective and gastroprotective
properties – they inhibit injuries of the gastric mucosa, induced by such factors as ethanol, stress, and medications abuse.
The scientifi c fi ndings seem to be very promising. Nevertheless, future studies are necessary in order to confi rm their potential
application in the treatment and/or prevention of gastrointestinal diseases in humans. Possibly, in the near future,
natural essential oils will be widely used instead of synthetic medicines.
REFERENCES (20)
1.
Madeira SVF, Matos FJA, Leal-Cardoso JH, Criddle DN. Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig. J Ethnopharmacol 2002;81:1-4.
2.
Hajhashemi V, Sadraei H, Ghannadi AR, Mohseni M. Antispasmodic and anti-diarrhoeal eff ect of Satureja hortensis L. essential oil. J Et nopharmacol 2000;71:187-192.
3.
Grabowska K, Ellnain M, Janeczko Z. Olejki eteryczne w leczeniu schorzeń przewodu pokarmowego. Aromaterapia 2009;3(57),15:34- 48.
4.
Lis-Balchi M, Hart S. Studies on the mode of action of the essential oil of Lavender (Lavandula angustifolia P. Miller). Phytother Res 1999;13:540- 542.
5.
Sadraei H, Ghannadi A, Malekshahi K. Relaxant eff ect of essential oil of Melissa offi cinalis and citral on rat ileum contractions. Fitoterapia 2003;74,5:445-452.
6.
Kastner U, Glasl S, Jurenitsch J. Achillea millefolium – A bile remedy? Refl ections about the actual use of an old medicinal plant. Z Phytother 1995;16:34-36.
7.
Mazzanti G, Lu M, Salvatore G. Spasmolytic action of the essential oil from Hyssopus offi cinalis L. var. decumbens and its major compo-nents. Phytother Res 1998;12:92-94.
8.
Tangpu V, Yadav AK. Antidiarrheal activity of Cymbopogon citratus and its main consituent, cytral. Pharmacologyonline 2006;2:290-298.
9.
Grabowska K, Ellnain M, Janeczko Z. Gastroprotekcyjne działanie olejkow eterycznych część 2. Aromaterapia 2010;4(62)16:12-19.
10.
Hasegawa C, Matsunaga T, Kawasuji T, Haruo S, Tadashi T, Rihei T, et al. Antiulcer Components in Essential Oil from Leaves of Crypto-meri japonica. Annual Report of Toyama prefectural Institute for Pharmaceutical Research 1999;26:39-43.
11.
Barocelli E, Calcina F, Chiavarini M, Impicciatore M, Bruni R, Bianchi A, et al. Antinociceptive and gastroprotective eff ects of inhaled and orally administered Lavandula hybrida Reverchon „Grosso” essential oil. Life Sci 2004;6:213-223.
12.
Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological eff ect of essentials oils. Review Food Chem Toxicol 2008;46:446-475.
13.
Grabowska K, Ellnain M, Janeczko Z. Gastroprotekcyjne działanie olejkow eterycznych część 1. Aromaterapia 2010;3(61)16:14-27.
14.
De Vries AC, Kuipers EJ, Rauws EAJ. Helicobacter pylori Eradication and Gastric Cancer: When Is the Horse Out of the Barn. Am J Gastroenterol 2009;104(6):1342-1345.
15.
Fritz E. Helicobacter pylori and gastric cancer. CME 2009;27(5):220- 222.
16.
Mahady BG, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, et al. In vitro susceptibility of Helicobacter pylori to botanical ex-tracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res 2005;19:988-991.
17.
Nakhaemi MM, Malekzadeh F, Khaje-Karamoddin M, Ramezani M. In vitro Anti-Helicobacter pylori Eff ects of Sweet Basil (Ocimum basilicum L.) and Purple Basil (Ocimum basilicum var. purpurascens. Pak J Biol Sci 2006;9,15:2887-2891.
18.
Ohno T, Kita M, Yamaoka Y, Imamura S, Yamamoto T, Mitsufuji S, et al. Antimicrobial Activity of Essential Oils against Helicobacter pylori. Helicobacter 2003;8:207-215.
19.
Ali SM, Khan AA, Ahmed I, Musaddiq M, Ahmed KS, Polasa H, et al. Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Ann Clin Microbiol Antimicrob 2005;4:20 doi:10.1186/1476-0711-4-20 www.ann-clinmicrob. com/content/4/1/20 (dostęp 2011-08-08).
20.
Lima CF, Sousa FD, Ferreira MJ, Lima Jr RCP, Tome AR, Cardoso JHL, et al. Croton zehntneri Essential Oils Prevents Acetaminophen Induced Acute Hepatotoxicity in Mice. Rec Nat Prod 2008;2:135-140.